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In summary, a browser is not a very stateful application, and there's not a lot to lock down. It's like a TV. So it's possible to take a relaxed attitude. If you do want to lock Firefox down, then there are a variety of ways to do it. You can put user profiles on a server, for example.
On deinstalling Internet Explorer, a tool like LitePC goes a long way to helping you do that in a rational manner. Most enterprises will want to remove the "big blue E" from the desktop, but leave the underlying libraries in place (since they're used by InfoPath and other tools).
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